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Elevated serum level of hepatocyte growth factor predicts development of new syndesmophytes in men with ankylosing spondylitis

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Elevated serum level of hepatocyte growth factor predicts development of new syndesmophytes in men with ankylosing spondylitis

Rheumatology Oxford Journal

Fecha de publicación: 4 de abril de 2021

DOI: https://doi.org/10.1093/rheumatology/keaa460

Autores: Anna Deminger, Eva Klingberg, Merja Nurkkala, Mats Geijer, Hans Carlsten, Lennart T H Jacobsson, Helena Forsblad-d’Elia

Background: To study baseline serum hepatocyte growth factor (s-HGF) as a predictor of spinal radiographic progression overall and by sex and to analyse factors correlated to changes in s-HGF in patients with AS. Methods: At baseline and the 5-year follow-up, s-HGF was analysed with ELISA. Spinal radiographs were graded according to modified Stoke Ankylosing Spondylitis Spinal Score. Radiographic progression was defined as ≥2 modified Stoke Ankylosing Spondylitis Spinal Score units/5 years or development of ≥1 syndesmophyte. Logistic regression analyses were used.

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