Epidermal Growth Factor Potentiates Migration of MDA-MB 231 Breast Cancer Cells by Increasing NaV1.5 Channel Expression

Oncology: International Journal of Cancer Research and Treatment

Fecha de publicación:

DOI: https://doi.org/10.1159/000501802

Autores: González-González L., González-Ramírez R., Flores A., Avelino-Cruz J.E., Felix R., Monjaraz E.

Background: Breast cancer is one of the leading causes of death worldwide and is the result of dysregulation of various signaling pathways in mammary epithelial cells. The mortality rate in patients suffering from breast cancer is high because the tumor cells have a prominent invasive capacity towards the surrounding tissues. Previous studies carried out in tumor cell models show that voltage-gated ion channels may be important molecular actors that contribute to the migratory and invasive capacity of the tumor cells.