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Establishment of a system to evaluate the therapeutic effect and the dynamics of an investigational drug on ulcerative colitis using human colonic organoids

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Establishment of a system to evaluate the therapeutic effect and the dynamics of an investigational drug on ulcerative colitis using human colonic organoids

Journal of Gastroenterology

Fecha de publicación: 1 january 2019

DOI: https://doi.org/10.1007/s00535-018-01540-y

Autores: Ryu Nishimura, Tomoaki Shirasaki, Kiichiro Tsuchiya, Yoshihide Miyake, Yusuke Watanabe, Shuji Hibiya, Sho Watanabe, Tetsuya Nakamura, Mamoru Watanabe.

Background: Ulcerative colitis (UC) is a chronic inflammatory disease of the colon with an intractable, recurrent course. The goal of UC therapy is to target mucosal healing because immune-suppressive therapy for UC frequently results in relapse. 

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