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Expansion of Alternative Autoantibodies Does Not Follow the Evolution of Anti–Citrullinated Protein Antibodies in Preclinical Rheumatoid Arthritis: An Analysis in At‐Risk First Degree Relatives

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Expansion of Alternative Autoantibodies Does Not Follow the Evolution of Anti–Citrullinated Protein Antibodies in Preclinical Rheumatoid Arthritis: An Analysis in At‐Risk First Degree Relatives

Arthritis & Rheumatology

Fecha de publicación: 3 de febrero de 2021

Autores: Vidyanand Anaparti, Irene Smolik, Xiaobo Meng, Liam O’Neil, Mackenzie A. Jantz, Marvin J. Fritzler, Hani El‐Gabalawy

DOI: https://doi.org/10.1002/art.41675

Background: Co‐occurrence of autoantibodies specific for ≥1 autoimmune disease is widely prevalent in rheumatoid arthritis (RA) patients. To understand the prevalence of polyautoimmunity in preclinical RA, we performed a comprehensive autoantibody assessment in a First Nations cohort of at‐risk first‐degree relatives (FDR) of RA patients, a subset of whom subsequently developed RA (progressors).

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