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Exploration of Coding and Non-coding Variants in Cancer Using GenomePaint

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Exploration of Coding and Non-coding Variants in Cancer Using GenomePaint

Cancer Cell

Fecha de publicación: 11 de Enero de 2021

DOI: https://doi.org/10.1016/j.ccell.2020.12.011

Autores: Jian Wang, Jaimin Patel, Marc Valentine, Ying Shao, Scott Newman, Edgar Sioson, Liqing Tian, Yu Liu, Samuel W. Brady, Diane Flasch, Xiaotu Ma, Yanling Liu, Robin Paul, Michael N. Edmonson, Michael C. Rusch, Chunliang Li, Suzanne J. Baker, John Easton, Jinghui Zhang

Summary: GenomePaint ( https://genomepaint.stjude.cloud/) is an interactive visualization platform for whole-genome, whole-exome, transcriptome, and epigenomic data of tumor samples. Its design captures the inter-relatedness between DNA variations and RNA expression, supporting in-depth exploration of both individual cancer genomes and full cohorts. Regulatory non-coding variants can be inspected and analyzed along with coding variants, and their functional impact further explored by examining 3D genome data from cancer cell lines.

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