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Extramedullary leukemia behaving as solid cancer: clinical, histologic, and genetic clues to chemoresistance in organ sites

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Extramedullary leukemia behaving as solid cancer: clinical, histologic, and genetic clues to chemoresistance in organ sites

American Journal of Hematology

Fecha de publicación: 28 July 2019

DOI: https://doi.org/10.1002/ajh.25594

Autores: Isabel Cunningham, Diane Hamele‐Bena, Yan Guo, Takayuki Shiomi, Audrey C. Papp, Bandana Chakravarti, Jianqi Yang, Yu Shyr, Rory A. Fisher.

Background: Recent studies of leukemic tumors in individual extramedullary sites showed they adopt the clinical and metastatic behavior of solid cancers originating in those sites. To elucidate features of leukemic tumors that render them resistant to agents effective against marrow leukemia, we analyzed a series of AML breast tumors by histology, immunohistochemistry, and RNA sequencing.

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