Genomic Characteristics of Myeloproliferative Neoplasms in Patients Exposed to Ionizing Radiation following the Chernobyl Nuclear Accident

American Journal of Hematology

Fecha de publicación: 8 october 2018

DOI: https://doi.org/10.1002/ajh.25307

Autores: Larysa Poluben MD., Maneka Puligandla MS., Donna Neuberg ScD., Christine R. Bryke MD., Yahsuan Hsu MS., Oleksandr Shumeiko MD., Xin Yuan MD, DSc., et al.

Background: Myeloproliferative neoplasms (MPNs) driver mutations are usually found in JAK2, MPL and CALR genes, however, 10‐15% of cases are triple negative (TN). A previous study showed lower rate of JAK2 V617F in Primary Myelofibrosis (PMF) patients exposed to low doses of ionizing radiation (IR) from Chernobyl accident.

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