Germline genetic patterns underlying across familial rheumatoid arthritis, systemic lupus erythematosus and primary Sjögren’s syndrome highlight T cell-initiated autoimmunity

Annals of the Rheumatic Diseases

Fecha de publicación: 17 December 2019

DOI: http://dx.doi.org/10.1136/annrheumdis-2019-215533

Autores: Yukai Wang, Shaoqi Chen, Jingyao Chen, Xuezhen Xie, Sini Gao, Chengpeng Zhang, Songxia Zhou, Jing Wang, Ruiqin Mai, Qisheng Lin, Jianqun Lin, Marco Matucci-Cerinic, Guohong Zhang, Daniel E Furst

Background: Familial aggregation of primary Sjögren’s syndrome (pSS), systemic lupus erythematosus (SLE), rheumatoid arthritis (RA) and co-aggregation of these autoimmune diseases (ADs) (also called familial autoimmunity) is well recognised. However, the genetic predisposition variants that explain this clustering remains poorly defined.