Gut epithelial impairment, microbial translocation and immune system activation in inflammatory bowel disease–associated spondyloarthritis

Rheumatology Oxford Journal

Fecha de publicación:  23 May 2020

DOI: https://doi.org/10.1093/rheumatology/keaa164

Autores: Michele Maria Luchetti, Francesco Ciccia, Chiara Avellini, Devis Benfaremo, Aroldo Rizzo, Tatiana Spadoni, Silvia Svegliati, Daniela Marzioni, Alfredo Santinelli, Andrea Costantini et al

Background: Gut microbiota has been widely reported to be involved in systemic inflammation through microbial translocation and T cell activation in several diseases. In this work we aimed to investigate bacterial infiltration and epithelial impairment in the gut of patients with IBD-associated SpA (SpA-IBD), as well as the relationship of microbial translocation with immune system activation and their putative role in the pathogenesis of joint inflammation in IBD patients.