Arthritis & Rheumatology
Fecha de publicación: 10 July 2020
DOI: https://doi.org/10.1002/art.41430
Autores: Willem J. J. Falkenburg, Nienke Oskam, Jana Koers,Laurette van Boheemen, Pleuni Ooijevaar‐de Heer, Gwenny M. Verstappen, Hendrika Bootsma, Frans G. M. Kroese, Dirkjan van Schaardenburg, Gertjan Wolbink, Theo Rispens.
Background: Rheumatoid factors (RFs), which are anti‐IgG autoantibodies strongly associated with rheumatoid arthritis (RA), are also found in other diseases and in healthy individuals. RFs bind to various epitopes in the constant (Fc‐) domain of IgG. Therefore, disease‐specific reactivity patterns may exist. This study was undertaken in order to develop a new approach to dissecting RF epitope binding patterns across different diseases.
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