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Identification of Clinically and Pathophysiologically Relevant Rheumatoid Factor Epitopes by Engineered IgG Targets

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Identification of Clinically and Pathophysiologically Relevant Rheumatoid Factor Epitopes by Engineered IgG Targets

Arthritis & Rheumatology

Fecha de publicación: 10 July 2020

DOI: https://doi.org/10.1002/art.41430

Autores: Willem J. J. Falkenburg, Nienke Oskam, Jana Koers,Laurette van Boheemen, Pleuni Ooijevaar‐de Heer, Gwenny M. Verstappen, Hendrika Bootsma, Frans G. M. Kroese, Dirkjan van Schaardenburg, Gertjan Wolbink, Theo Rispens.

Background: Rheumatoid factors (RFs), which are anti‐IgG autoantibodies strongly associated with rheumatoid arthritis (RA), are also found in other diseases and in healthy individuals. RFs bind to various epitopes in the constant (Fc‐) domain of IgG. Therefore, disease‐specific reactivity patterns may exist. This study was undertaken in order to develop a new approach to dissecting RF epitope binding patterns across different diseases.

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