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Identification of the skeletal progenitor cells forming osteophytes in osteoarthritis

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Identification of the skeletal progenitor cells forming osteophytes in osteoarthritis

Annals of the Rheumatic Diseases

Fecha de publicación:  September 22, 2020.

DOI: http://dx.doi.org/10.1136/annrheumdis-2020-218350

Autores: Anke J Roelofs, Karolina Kania, Alexandra J Rafipay, Meike Sambale, Stephanie T Kuwahara, Fraser L Collins, Joanna Smeeton, Maxwell A Serowoky, Lynn Rowley, Hui Wang, René Gronewold, Chrysa Kapeni, Simón Méndez-Ferrer, Christopher B Little, John F Bateman, Thomas Pap, Francesca V Mariani3, Joanna Sherwood, J Gage Crump, Cosimo De Bari

Background: Osteophytes are highly prevalent in osteoarthritis (OA) and are associated with pain and functional disability. These pathological outgrowths of cartilage and bone typically form at the junction of articular cartilage, periosteum and synovium. The aim of this study was to identify the cells forming osteophytes in OA.

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