Impact of gastrointestinal disease states on oral drug absorption – implications for formulation design – a PEARRL review

Journal of Pharmacy and Pharmacology

Fecha de publicación: 16 may 2018

DOI: https://doi.org/10.1111/jphp.12928

Autores: Angela Effinger Caitriona M. O’Driscoll Mark McAllister Nikoletta Fotaki.

Background: Drug product performance in patients with gastrointestinal (GI) diseases can be altered compared to healthy subjects due to pathophysiological changes. In this review, relevant differences in patients with inflammatory bowel diseases, coeliac disease, irritable bowel syndrome and short bowel syndrome are discussed and possible in vitro and in silico tools to predict drug product performance in this patient population are assessed.