
Annals of the Rheumatic Diseases
Fecha de publicación: 7 May 2020
DOI: http://dx.doi.org/10.1136/annrheumdis-2020-217200
Autores: Sizheng Steven Zhao, Houchen Lyu, Daniel H Solomon, Kazuki Yoshida
Background: Target trial emulation is an intuitive design framework that encourages investigators to formulate their comparative effectiveness research (CER) question as a hypothetical randomised controlled trial (RCT). Our aim was to systematically review CER studies in rheumatoid arthritis (RA) to provide examples of design limitations that could be avoided using target trial emulation, and how these limitations might introduce bias.
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