
Journal of Pharmacy and Pharmacology
Fecha de publicación: 29 April 2019
DOI: https://doi.org/10.1111/jphp.13100
Autores: Suqin Feng, Liang Zheng, Shiwei Tang, Juan Gu, Xuehua Jiang, Ling Wang.
Background: Antidepressants need to penetrate the blood–brain barrier (BBB) to exert their functions in the central nervous system. Breast cancer resistance protein (BCRP), an efflux transporter abundantly expressed in the BBB, prevents the accumulation of many drugs in the brain. This study aimed to identify whether five commonly used antidepressants (sertraline, duloxetine, fluoxetine, amitriptyline and mirtazapine) are BCRP substrates.
Leer más
Comentarios
Para dejar un comentario antes debes iniciar sesión:
¿No tienes una cuenta?
Regístrate a través de éste enlace.