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Incomplete excision of cervical precancer as a predictor of treatment failure: a systematic review and meta-analysis

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Incomplete excision of cervical precancer as a predictor of treatment failure: a systematic review and meta-analysis

The Lancet Oncology

Published: 07 November 2017

DOI: http://dx.doi.org/10.1016/S1470-2045(17)30700-3

Marc Arbyn, Charles W E Redman, MD, Freija Verdoodt, PhD, Maria Kyrgiou, PhD, Menelaos Tzafetas, MD, Sadaf Ghaem-Maghami, PhD, Prof Karl-Ulrich Petry, PhD, Simon Leeson, MD, Christine Bergeron, PhD, Prof Pekka Nieminen, PhD, Prof Jean Gondry, PhD, Olaf Reich, MD, Esther L Moss, PhD

Background: Incomplete excision of cervical precancer is associated with therapeutic failure and is therefore considered as a quality indicator of clinical practice. Conversely, the risk of preterm birth is reported to correlate with size of cervical excision and therefore balancing the risk of adequate treatment with iatrogenic harm is challenging. We reviewed the literature with an aim to reveal whether incomplete excision, reflected by presence of precancerous tissue at the section margins, or post-treatment HPV testing are accurate predictors of treatment failure.
  

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