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Individualised versus standard duration of elastic compression therapy for prevention of post-thrombotic syndrome (IDEAL DVT): a multicentre, randomised, single-blind, allocation-concealed, non-inferiority trial

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Individualised versus standard duration of elastic compression therapy for prevention of post-thrombotic syndrome (IDEAL DVT): a multicentre, randomised, single-blind, allocation-concealed, non-inferiority trial

The Lancet Haematology

Published:  04 December 2017

DOI: http://dx.doi.org/10.1016/S2352-3026(17)30227-2

Arina J ten Cate-Hoek, Elham E Amin, MD, Annemieke C Bouman, MD, Prof Karina Meijer, MD, Lidwine W Tick, MD, Prof Saskia Middeldorp, MD, Guy J M Mostard, MD, Marije ten Wolde, MD, Simone M van den Heiligenberg, MD, Sanne van Wissen, MD, Marlène HW van de Poel, MD, Sabina Villalta, MD, Erik H Serné, MD, Hans-Martin Otten, MD, Edith H Klappe, MD, Ingrid M Bistervels, MD, Mandy N Lauw, MD, Margriet Piersma-Wichers, MD, Prof Paolo Prandoni, MD, Prof Manuela A Joore, PhD, Prof Martin H Prins, MD, Prof Hugo ten Cate, MD

Background: Therapy with elastic compression stockings has been the cornerstone for prevention of post-thrombotic syndrome for decades in patients after acute deep venous thrombosis. It is uncertain who benefits most from therapy, and what the optimum duration of therapy should be. We therefore aimed to assess the safety and efficacy of individualised duration of compression therapy versus the standard duration of 24 months following an initial treatment period of 6 months.

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