Journal of Pharmacy and Pharmacology
First published: 13 December 2017
DOI: 10.1111/jphp.12853
Bing Yang, Shouying Du, Yang Lu, Shan Jia, Mengdi Zhao, Jie Bai, Pengyue Li, Huichao Wu
Objective: Our objective of this research was (1) to investigate the transport characteristics of puerarin through MDCK-MDR1 and MDCK cells and (2) to evaluate the effects of paeoniflorin and menthol on puerarin transport so as to (3) explore the enhancement mechanism.
Methods: The cytotoxicity of drugs on MDCK and MDCK-MDR1 was evaluated by the MTT assay, and the transport studies were performed in both directions.
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