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Influence of paeoniflorin and menthol on puerarin transport across MDCK and MDCK-MDR1 cells as blood–brain barrier in vitro model

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Influence of paeoniflorin and menthol on puerarin transport across MDCK and MDCK-MDR1 cells as blood–brain barrier in vitro model

Journal of Pharmacy and Pharmacology

First published:  13 December 2017
DOI:
10.1111/jphp.12853

Bing Yang, Shouying Du, Yang Lu, Shan Jia, Mengdi Zhao, Jie Bai, Pengyue Li, Huichao Wu

Objective: Our objective of this research was (1) to investigate the transport characteristics of puerarin through MDCK-MDR1 and MDCK cells and (2) to evaluate the effects of paeoniflorin and menthol on puerarin transport so as to (3) explore the enhancement mechanism.

Methods: The cytotoxicity of drugs on MDCK and MDCK-MDR1 was evaluated by the MTT assay, and the transport studies were performed in both directions. 

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