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Lactate Lights up PI3K Inhibitor Resistance in Breast Cancer

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Lactate Lights up PI3K Inhibitor Resistance in Breast Cancer

Cancer Cell

Fecha de publicación: September 2020

DOI: https://doi.org/10.1016/j.ccell.2020.09.011

Autores: Alissandra L. Hillis, Alex Toker

Background: Predictive biomarkers can facilitate optimal patient selection for targeted cancer therapies. In this issue of Cancer Cell, Ros et al. show the utility of noninvasive metabolic imaging of labeled carbon transfer from pyruvate to lactate to detect early response and FOXM1-mediated resistance to PI3K inhibition in estrogen-receptor-positive breast cancer.

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