Mate pair sequencing improves detection of genomic abnormalities in acute myeloid leukemia

European Journal of Heamatology

Fecha de publicación: 1 october 2018

DOI: https://doi.org/10.1111/ejh.13179

Autores: Larysa Poluben MD., Maneka Puligandla MS., Donna Neuberg ScD., Christine R. Bryke MD., Yahsuan Hsu MS., Oleksandr Shumeiko MD., Xin Yuan MD, DSc., et al.

Background: Acute myeloid leukemia (AML) can be subtyped based on recurrent cytogenetic and molecular genetic abnormalities with diagnostic and prognostic significance. Although cytogenetic characterization classically involves conventional chromosome and/or fluorescence in situ hybridization (FISH) assays, limitations of these techniques include poor resolution and the inability to precisely identify breakpoints.

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