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Multi-regional sequencing reveals clonal and polyclonal seeding from primary tumor to metastases in advanced gastric cancer

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Multi-regional sequencing reveals clonal and polyclonal seeding from primary tumor to metastases in advanced gastric cancer

Journal of Gastroenterology

Fecha de publicación: 7 January 2019

DOI: https://doi.org/10.1007/s00535-019-01659-6

Autores: Yosuke Hirotsu, Masao Hada, Kenji Amemiya, Toshio Oyama, Hitoshi Mochizuki, Masao Omata

Background: Tumor metastases to lymph nodes and distant organs are associated with worse prognosis in gastric cancer. However, little is known about the genetic profiles, subclonal architecture, and evolutional processes across primary tumors and metastases.

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