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Neurofibromin Is an Estrogen Receptor-α Transcriptional Co-repressor in Breast Cancer

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Neurofibromin Is an Estrogen Receptor-α Transcriptional Co-repressor in Breast Cancer

Cancer Cell

Fecha de publicación: 5 March 2020

DOI: https://doi.org/10.1016/j.ccell.2020.02.003

Autores: Ze-Yi Zheng, Meenakshi Anurag, Jonathan T. Lei, Charles E. Foulds, Matthew J. Ellis, Eric C. Chang, et al.
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Background: We report that neurofibromin, a tumor suppressor and Ras-GAP (GTPase-activating protein), is also an estrogen receptor-α (ER) transcriptional co-repressor through leucine/isoleucine-rich motifs that are functionally independent of GAP activity. GAP activity, in turn, does not affect ER binding.

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