Non-alcoholic fatty liver disease: a multisystem disease requiring a multidisciplinary and holistic approach

The Lancet Gastroenterology & Hepatology

Fecha de publicación:

Autores: Prof Giovanni Targher, MD , Prof Herbert Tilg, MD, Prof Christopher D Byrne, MB BCh

DOI: https://doi.org/10.1016/S2468-1253(21)00020-0

Background: Non-alcoholic fatty liver disease (NAFLD) is a public health problem worldwide. This narrative Review provides an overview of the current literature to support the notion that NAFLD is a multisystem disease. Convincing evidence shows a strong association between NAFLD and the risk of developing multiple extrahepatic complications such as type 2 diabetes, cardiovascular disease (ie, the predominant cause of mortality in people with NAFLD), chronic kidney disease, and some types of extrahepatic malignancies.

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