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Particle Analysis of Biotherapeutics in Human Serum using Machine Learning

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Particle Analysis of Biotherapeutics in Human Serum using Machine Learning

Journal of Pharmaceutical Sciences

Fecha de publicación: 26 February 2020

DOI: https://doi.org/10.1016/j.xphs.2020.02.015

Autores: Joachim Schuster, Atanas Koulov, Hanns-Christian Mahler, Susanne Joerg, Joerg Huwyler, Kai Schleicher, Pascal Detampel

Background: In recent years, an increasing number of studies assessed the stability of biotherapeutics in biological fluids. Such studies aim to simulate the conditions encountered in the human body and investigate the in vivo stability under in vitro conditions. However, due to complexity of biological fluids, standard pharmaceutical methods are poorly suited to assess the stability of biotherapeutics.

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