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Pathogenesis of Diffuse Alveolar Hemorrhage in Murine Lupus

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Pathogenesis of Diffuse Alveolar Hemorrhage in Murine Lupus

Arthritis & Rheumatology
First published:
5 May 2017
DOI:
10.1002/art.40077

Haoyang Zhuang, Shuhong Han, Pui Y. Lee, Ravil Khaybullin, Stepan Shumyak, Li Lu, Amina Chatha, Anan Afaneh, Yuan Zhang, Chao Xie, Dina Nacionales, Lyle Moldawer, Xin Qi, Li-Jun Yang, Westley H. Reeves

Objective: Diffuse alveolar hemorrhage (DAH) in lupus patients confers >50% mortality, and the cause is unknown. We undertook this study to examine the pathogenesis of DAH in C57BL/6 mice with pristane-induced lupus, a model of human lupus-associated DAH.
Methods: Clinical/pathologic and immunologic manifestations of DAH in pristane-induced lupus were compared with those of DAH in humans. Tissue distribution of pristane was examined by mass spectrometry. Cell types responsible for disease were determined by in vivo depletion…

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