Prevalence and Characteristics of Persistent Clonal T Cell Large Granular Lymphocyte Expansions in Rheumatoid Arthritis

Arthritis and Rheumatology

Fecha de publicación: 25 june 2018

DOI: https://doi.org/10.1002/art.40654

Autores: Eva C. Schwaneck MD., Regina Renner MA., Lara Junker MD., Hermann Einsele MD., Ottar Gadeholt MD., Eva Geissinger MD., Stefan Kleinert MD., Michael Gernert MD.

Background: Up to one‐third of patients with T cell large granular lymphocyte (T‐LGL) leukemia display symptoms of rheumatoid arthritis (RA). In Crohn’s disease and psoriasis, treatment with tumor necrosis factor (TNF) inhibitors is associated with hepatosplenic γδ T cell lymphoma and with clonal expansion of γδ T cells, respectively.

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