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Recommended strategies for the oral administration of paediatric medicines with food and drinks in the context of their biopharmaceutical properties: a review

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Recommended strategies for the oral administration of paediatric medicines with food and drinks in the context of their biopharmaceutical properties: a review

Journal of Pharmacy and Pharmacology
Volume 69, Issue 4, April 2017, Pages 384–397

Joana Martir,
 Talia Flanagan,
 


James Mann, Nikoletta Fotaki

Abstract

ObjectivesThis review focuses on the recommended strategies for the oral administration of paediatric medicines with food in the context of their biopharmaceutical properties.
Key findingsAcceptability of oral medicines in young patients is more challenging than in adult patients. Mixing oral dosage forms with foods and drinks is sometimes suggested to administer a specific dose and enhance compliance in the paediatric population. In this review, the strategies for the co-administration of paediatric medicines with food and drinks are discussed. Current administration practices as reported by healthcare professionals and parents/carers are compared with the relevant guidelines. Differences in the type of vehicles recommended to be used and actually used in current practice were identified. Correlations of the type of food recommended, the type of formulation and the drug’s biopharmaceutical classification system (BCS) class were performed and revealed that recommendations should be made on a case-by-case basis.SEGUIR LEYENDO

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