
Annals of the Rheumatic Diseases
Fecha de publicación: 17 de Enero de 2021
DOI: http://dx.doi.org/10.1136/annrheumdis-2020-219545
Autores: Salvatore Minisola, Jessica Pepe, Cristiana Cipriani
Summary: Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory condition that leads, per se, to bone loss by three main mechanisms. The first one is represented by bone erosions around the involved joints. Second, there is focal subchondral bone loss owing to increased osteoclast activity. Finally, systemic inflammation causes universal bone loss, mainly manifesting at the axial skeleton (ie, vertebral bodies and hip).
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