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Safety of direct oral anticoagulant exposure during pregnancy: a retrospective cohort study

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Safety of direct oral anticoagulant exposure during pregnancy: a retrospective cohort study

The Lancet Haematology

Fecha de publicación: December, 2020

DOI: https://doi.org/10.1016/S2352-3026(20)30327-6

Autores: Prof Jan Beyer-Westendorf, MD , Luise Tittl, BS, Ingrid Bistervels, MD, Prof Saskia Middeldorp, MD, Prof Christof Schaefer, MD, Wolfgang Paulus, MD et al.

Background: Direct oral anticoagulants (DOACs) have largely replaced vitamin K antagonists in many indications for anticoagulation. Prescribed to millions of patients, including women of reproductive age, exposure to DOACs in early pregnancy is not uncommon, but data on the embryotoxic risks are scarce. We aimed to assess the risk of DOAC embryotoxicity in a large sample of reported cases.

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