Secretory form of rheumatoid arthritis–associated autoantibodies in serum are mainly of the IgM isotype, suggesting a continuous reactivation of autoantibody responses at mucosal surfaces

Annals of the Rheumatic Diseases

Fecha de publicación: August 14, 2018

DOI: http://dx.doi.org/10.1136/annrheumdis-2018-213724

Autores: Myrthe A M van Delft, Diane van der Woude, René E M Toes, Leendert A Trouw.

Background: Several lines of evidence obtained in recent years indicate a role of mucosal surfaces in the development of autoimmune responses associated with rheumatoid arthritis (RA). Therefore, more attention is going to the influence of the microbiome in RA development.

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