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Severe dysautonomia as a manifestation of neurotoxicity after CAR‐T cell therapy for diffuse large B‐cell lymphoma

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Severe dysautonomia as a manifestation of neurotoxicity after CAR‐T cell therapy for diffuse large B‐cell lymphoma

American Journal of Hematology

Fecha de publicación: 31 March 2020

DOI: https://doi.org/10.1002/ajh.25794

Autores: Firas El Chaer, Ariel Siegel, Noa G. Holtzman, Ali Bukhari, Forat Lutfi, Nirav G. Shah, Jean A. Yared, Aaron P. Rapoport, Michael T. McCurdy, Saurabh Dahiya

Background: Anti‐CD19 chimeric antigen receptor T‐cell (CART) therapy is associated with off‐ and on‐target adverse effects including cytokine release syndrome (CRS) and immune effector cell‐associated neurotoxicity syndrome (ICANS).

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