Steroidal saponins from Trillium govanianum as α-amylase, α-glucosidase, and dipeptidyl peptidase IV inhibitory agents

Journal of Pharmacy and Pharmacology

Fecha de publicación: 16 de enero de 2021

DOI: https://doi.org/10.1093/jpp/rgaa038

Autores: Patil Shivprasad Suresh, Prithvi Pal Singh, Yogendra S Padwad, Upendra Sharma

Background: To provide the scientific basis for the utility of rhizome of Trillium govanianum as nutraceutical supplements in managing physiological glycemic levels. Methods: The in vitro enzyme inhibitory activity of the extract, fractions, and the isolated steroidal saponins from the rhizome part of T. govanianum was carried out against α-amylase, α-glucosidase, and dipeptidyl peptidase IV. The molecular interactions, binding score, and pharmacokinetic parameters (absorption, distribution metabolism, and excretion) of steroidal saponins were analyzed by the Schrodinger molecular docking software.