Alimentary Pharmacology & Therapeutics
Fecha de publicación: 11 september 2018
Autores: Ahmed Albusoda, James K. Ruffle, Kathrine A. Friis, Maximilian R. Gysan, Asbjørn M. Drewes, Qasim Aziz, Adam D. Farmer
Backgrounds: Irritable bowel syndrome (IBS) is common and is characterised by recurrent abdominal pain, which is a major contributor to healthcare seeking. The neurobiological basis of this pain is incompletely understood. Conditioned pain modulation is a neuromodulatory mechanism through which the brain inhibits the nociceptive afferent barrage through the descending pathways. Reduced conditioned pain modulation has been implicated in the pathophysiology of IBS, although to date only in studies with relatively small sample sizes.