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Systematic review with network meta-analysis: first- and second-line pharmacotherapy for moderate-severe ulcerative colitis

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Systematic review with network meta-analysis: first- and second-line pharmacotherapy for moderate-severe ulcerative colitis

Alimentary Pharmacology & Therapeutics

First published: 4 December 2017

DOI: 10.1111/apt.14422

S. Singh, M. Fumery, W. J. Sandborn, M. H. Murad

Objective: There are limited data to inform positioning of agents for treating moderate-severe ulcerative colitis (UC).

Methods: We identified randomised controlled trials (RCTs) in adults with moderate-severe UC treated with anti-TNF agents, anti-integrin agents and janus kinase (JAK) inhibitors, as first-line or second-line agents, and compared with placebo or another active agent. 
  

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