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Systemic evaluation of the relationship between psoriasis, psoriatic arthritis and osteoporosis: observational and Mendelian randomisation study

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Systemic evaluation of the relationship between psoriasis, psoriatic arthritis and osteoporosis: observational and Mendelian randomisation study

Annals of the Rheumatic Diseases

Fecha de publicación: July 31, 2020

DOI: http://dx.doi.org/10.1136/annrheumdis-2020-217892

Autores: Jiangwei Xia, Shu-Yang Xie, Ke-Qi Liu, Lin Xu, Pian-Pian Zhao, Si-Rui Gai, Peng-Lin Guan, Jin-Qiu Zhao, Yan-Ping Zhu, Lam C Tsoi, Philip E Stuart, Rajan P Nair, Han-Qi Yang, Yu-Ting Liao, Kaijing Mao, Mo-Chang Qiu, Zhi-Min Ying, Bin Hu, Zhi-Hua Yang, Wei-Yang Bai, Xiao-Wei Zhu,Pei-Kuan Cong, James T Elder, Zhao-Ming Ye, Bin Wang, Hou-Feng Zheng

Background: With 432 513 samples from UK Biobank dataset, multivariable linear/logistic regression were used to estimate the relationship between psoriasis/psoriatic arthritis (PsA) and estimated bone mineral density (eBMD)/osteoporosis, controlling for potential confounders. Here, confounders were set in three ways: model0 (including age, height, weight, smoking and drinking), model1 (model0 +regular physical activity) and model2 (model1 +medication treatments). The eBMD was derived from heel ultrasound measurement. And 4904 patients with psoriasis and 847 patients with PsA were included in final analysis. Mendelian randomisation (MR) approach was used to evaluate the causal effect between them.

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