The role of a clinical pharmacist in spurious Penicillin allergy: a narrative review

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The role of a clinical pharmacist in spurious Penicillin allergy: a narrative review

International Journal of Clinical Pharmacy

Fecha de publicación: 13 de enero de 2021

DOI: https://doi.org/10.1007/s11096-020-01226-7

Autores: Rashmeet Bhogal, Abid Hussain, Ariyur Balaji, William H. Bermingham, John F. Marriott & Mamidipudi T. Krishna 

Background: A label of penicillin allergy is held by 6–10% of the general population and 15–20% of inpatients. > 90% of these labels are found to be spurious after formal allergy assessment. Carrying an unnecessary label of penicillin allergy is not benign. Such patients may receive second line, more expensive antibiotics, representing a significant impediment to antimicrobial stewardship. Aim of the review To (a) Explain the burden of spurious penicillin allergy, and evaluate the safety of direct oral penicillin challenge in ‘low risk’ patients (b) appraise the place for a clinical pharmacist-led penicillin allergy de-labelling programme. Method Narrative review.

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