Journal of Gastroenterology
Fecha de publicación: 16 August 2017
Autores: Chunwei Peng, Jiuyang Liu, Guifang Yang, Yan Li
Background: Insufficient attention is paid to the underlying tumor microenvironment (TME) evolution, that resulting in tumor heterogeneity and driving differences in cancer aggressiveness and treatment outcomes. The morphological evaluation of the proportion of the stroma at the most invasive part of primary tumor (tumor-stromal ratio, TSR) in cancer is gaining momentum as evidence strengthens for the clinical relevance.