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Tumor and immune reprogramming during immunotherapy in advanced renal cell carcinoma

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Tumor and immune reprogramming during immunotherapy in advanced renal cell carcinoma

Cancer Cell

Fecha de publicación: 11 de marzo de 2021

DOI: https://doi.org/10.1016/j.ccell.2021.02.015

Autores: Kevin Bi, Meng Xiao He, Ziad Bakouny, Abhay Kanodia, Sara Napolitano, Jingyi Wu, Grace Grimald, David A.Braun, Michael S.Cuoco, Angie Mayorga, Laura Dello Stritto, Gabrielle Bouchard, John Steinharter, et al.

Background: Immune checkpoint blockade (ICB) results in durable disease control in a subset of patients with advanced renal cell carcinoma (RCC), but mechanisms driving resistance are poorly understood. We characterize the single-cell transcriptomes of cancer and immune cells from metastatic RCC patients before or after ICB exposure. In responders, subsets of cytotoxic T cells express higher levels of co-inhibitory receptors and effector molecules.

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