Fecha de publicación: 01 november 2018
Autores: Craig M. Bielski, Mark T.A. Donoghue, Mayur Gadiya, Sarat Chandarlapaty, Michael F. Berger, Barry S. Taylor, et al.
Background: Driver mutations in oncogenes encode proteins with gain-of-function properties that enhance fitness. Heterozygous mutations are thus viewed as sufficient for tumorigenesis. We describe widespread oncogenic mutant allele imbalance in 13,448 prospectively characterized cancers.