Journal of the American Pharmacists Association
March–April, 2017 Volume 57, Issue 2, Pages 155–161.e1
Penjit Moorhead, Ana Zavala, Yoona Kim, Naunihal S. Virdi
Abstract
Objectives
Over one-half of patients with chronic diseases, such as hypertension and type 2 diabetes (DM), do not take medicines as prescribed. This study assessed the efficacy and safety of “seeing” versus “not seeing” medication dose reminders regarding medication adherence and risk for overdose.
Design
Post hoc analysis.
Setting and participants
Outpatient setting. Adult subjects (18 years of age or older) with uncontrolled hypertension and DM.
Main outcome measures
Subjects enrolled in this institutional review board–approved study were assigned to either use digital health (DH) with the use of sensor-enabled medicines (coencapsulated medicines with an ingestible sensor) for 4 or 12 weeks or receive usual care based on a cluster-randomized design. All subjects were followed for 12 weeks. Subjects using DH were included in the post hoc study consisting of an efficacy analysis and a safety analysis. A main efficacy outcome of comparison of subjects taking medicine with or without “seeing” DH medication dose reminders was assessed. Safety analysis assessed risk of overdosing after DH medication dose reminders.
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