Fecal microbiota transfer for refractory intestinal graft-versus-host disease — Experience from two German tertiary centers

European Journal of Hematology

Fecha de publicación: 2 de mayo de 2021

Autores: Felix Goeser, Barbara Sifft, Christoph Stein-Thoeringer, Fedja Farowski, Christian P. Strassburg, Peter Brossart, Paul G. Higgins, Christoph Scheid, Dominik Wolf, Tobias A. W. Holderried, Maria J. G. T. Vehreschild, Marta Rebeca Cruz Aguilar

DOI: https://doi.org/10.1111/ejh.13642

Background: Steroid refractory graft-vs-host disease (sr-GvHD) represents a challenging complication after allogeneic hematopoietic cell transplantation (allo-HCT). Intestinal microbiota (IM) diversity and dysbiosis were identified as influencing factors for the development of acute GvHD. Fecal microbiota transfer (FMT) is hypothesized to restore IM dysbiosis, but there is limited knowledge about the significance of FMT in the treatment of sr-GvHD

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