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Reversal of Sepsis‐Like Features of Neutrophils by Interleukin‐1 Blockade in Patients With Systemic‐Onset Juvenile Idiopathic Arthritis

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Reversal of Sepsis‐Like Features of Neutrophils by Interleukin‐1 Blockade in Patients With Systemic‐Onset Juvenile Idiopathic Arthritis
Arthritis & Rheumatology
 

Fecha de publicación: 09 February 2018 

DOI: https://doi.org/10.1002/art.40442

Autores: Nienke M. ter Haar MD Tamar Tak PhD Michal Mokry PhD Rianne C. Scholman Jenny M. Meerding Wilco de Jager PhD Anouk Verwoerd MD Dirk Foell MD, PhD Thomas Vogl PhD … 

Background: Neutrophils are the most abundant innate immune cells in the blood, but little is known about their role in (acquired) chronic autoinflammatory diseases. This study was undertaken to investigate the role of neutrophils in systemic‐onset juvenile idiopathic arthritis (JIA), a prototypical multifactorial autoinflammatory disease that is characterized by arthritis and severe systemic inflammation.

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